Name: FGFR4-IN-5
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321633
Cas No:1628793-01-0
常用名:FGFR4-IN-5
别名:FGFR4-IN-5
IUPAC:N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide
IUPAC:N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide
InChI key:ZIJVLVUPDVUSMA-UONOGXRCSA-N

分子式:C23H23Cl2N5O5
分子量:520.37
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O
SMILES:COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O

FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1].

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