Name: CAY10771
Rating: 5 (10 reviews)

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HIT ID:HIT214321647
Cas No:2522599-79-5
常用名:CAY10771
IUPAC:2-(4-{[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)methyl]amino}phenyl)acetic acid
IUPAC:2-(4-{[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)methyl]amino}phenyl)acetic acid
InChI key:SPZFHDGEKBUECT-UHFFFAOYSA-N

分子式:C28H25Cl3N2O4
分子量:559.87
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)c1onc(c1COc1ccc(CNc2ccc(CC(O)=O)cc2)c(Cl)c1)-c1c(Cl)cccc1Cl
SMILES:CC(C)c1onc(c1COc1ccc(CNc2ccc(CC(O)=O)cc2)c(Cl)c1)-c1c(Cl)cccc1Cl

CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM.

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