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HIT214321681
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HIT214321681
  • HIT ID:HIT214321681
  • Cas No:1019640-33-5
  • 常用名:Sitamaquine tosylate
  • IUPAC:4-methylbenzene-1-sulfonic acid; N-[6-(diethylamino)hexyl]-6-methoxy-4-methylquinolin-8-amine
    IUPAC:4-methylbenzene-1-sulfonic acid; N-[6-(diethylamino)hexyl]-6-methoxy-4-methylquinolin-8-amine
  • InChI key:LOBPWLFCZDGYKW-UHFFFAOYSA-N
  • 分子式:C28H41N3O4S
  • 分子量:515.71
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cc1ccc(cc1)S(O)(=O)=O.CCN(CC)CCCCCCNc1cc(OC)cc2c(C)ccnc12
    SMILES:Cc1ccc(cc1)S(O)(=O)=O.CCN(CC)CCCCCCNc1cc(OC)cc2c(C)ccnc12
  • Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes.
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    TargetMolSC
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