Name: 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
Rating: 5 (10 reviews)

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HIT ID:HIT214321688
Cas No:154436-49-4
常用名:1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
常用名:1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
IUPAC:(2-aminoethoxy)[(2R)-2-{[(5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoyl]oxy}-3-(octadecanoyloxy)propoxy]phosphinic acid
IUPAC:(2-aminoethoxy)[(2R)-2-{[(5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoyl]oxy}-3-(octadecanoyloxy)propoxy]phosphinic acid
InChI key:ILISYDMFRZNALR-AQLFUWFLSA-N

分子式:C43H78NO10P
分子量:800.068
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCCC)OO
SMILES:CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCC\C=C/C\C=C/C\C=C/C=C/[C@H](CCCCC)OO

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

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