Name: MCTR1
Rating: 5 (10 reviews)

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HIT ID:HIT214321701
Cas No:1784701-61-6
常用名:MCTR1
别名:MCTR1
IUPAC:(4Z,7Z,9E,11E,13R,14S,16Z,19Z)-13-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-14-hydroxydocosa-4,7,9,11,16,19-hexaenoic acid
IUPAC:(4Z,7Z,9E,11E,13R,14S,16Z,19Z)-13-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-14-hydroxydocosa-4,7,9,11,16,19-hexaenoic acid
InChI key:NWYKIASJHFGEAN-CPMAONNBSA-N

分子式:C32H47N3O9S
分子量:649.8
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC\C=C/C\C=C/C[C@H](O)[C@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)\C=C\C=C\C=C/C\C=C/CCC(O)=O
SMILES:CC\C=C/C\C=C/C[C@H](O)[C@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)\C=C\C=C\C=C/C\C=C/CCC(O)=O

Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.

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