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  3. HIT214321714
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HIT214321714
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HIT214321714
  • HIT ID:HIT214321714
  • Cas No:348079-12-9
  • 常用名:Fura-FF AM
  • IUPAC:(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(5-{[(acetyloxy)methoxy]carbonyl}-1,3-oxazol-2-yl)-5-(2-{6-[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]-2,3-difluorophenoxy}ethoxy)-1-benzofuran-6-yl]amino)acetate
    IUPAC:(acetyloxy)methyl 2-({2-[(acetyloxy)methoxy]-2-oxoethyl}[2-(5-{[(acetyloxy)methoxy]carbonyl}-1,3-oxazol-2-yl)-5-(2-{6-[bis({2-[(acetyloxy)methoxy]-2-oxoethyl})amino]-2,3-difluorophenoxy}ethoxy)-1-benzofuran-6-yl]amino)acetate
  • InChI key:FPUWXSBNYDMTRN-UHFFFAOYSA-N
  • 分子式:C43H43F2N3O24
  • 分子量:1023.811
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1cc2oc(cc2cc1OCCOc1c(F)c(F)ccc1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c1ncc(o1)C(=O)OCOC(C)=O
    SMILES:CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1cc2oc(cc2cc1OCCOc1c(F)c(F)ccc1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c1ncc(o1)C(=O)OCOC(C)=O
  • Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) . As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a difluorinated derivative of the calcium indicator fura-2 . Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation. Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 μM, respectively). However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presence of a high calcium concentration. Low affinity calcium dyes, including fura-FF, are preferred for studying compartments with high concentrations of calcium, such as mitochondria, or in cell systems that have relatively low calcium buffering capacities, such as neuronal dendrites and spines.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,590.00
    1

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