Name: Glycerophospho-N-Arachidonoyl Ethanolamine
Rating: 5 (10 reviews)

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HIT ID:HIT214321720
Cas No:201738-25-2
常用名:Glycerophospho-N-Arachidonoyl Ethanolamine
常用名:Glycerophospho-N-Arachidonoyl Ethanolamine
IUPAC:(2,3-dihydroxypropoxy)({2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido]ethoxy})phosphinic acid
IUPAC:(2,3-dihydroxypropoxy)({2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenamido]ethoxy})phosphinic acid
InChI key:PAGKVQGBMADPCS-DOFZRALJSA-N

分子式:C25H44NO7P
分子量:501.601
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCOP(O)(=O)OCC(O)CO
SMILES:CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCOP(O)(=O)OCC(O)CO

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-arachidonoyl ethanolamine is the precursor of arachidonoyl ethanolamide (AEA), also known as anandamide. AEA is an endogenous cannabinoid neurotransmitter that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for δ9-THC.

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