Name: 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321769
Cas No:1233715-28-0
常用名:17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
常用名:17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
IUPAC:(4Z,7Z,10Z,13Z,15E,19Z)-17-oxodocosa-4,7,10,13,15,19-hexaenoic acid
IUPAC:(4Z,7Z,10Z,13Z,15E,19Z)-17-oxodocosa-4,7,10,13,15,19-hexaenoic acid
InChI key:QCEBQMMZCFADMF-VIIQGJSXSA-N

分子式:C22H30O3
分子量:342.479
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC\C=C/CC(=O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O
SMILES:CC\C=C/CC(=O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

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