Name: CAY10498
Rating: 5 (10 reviews)

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HIT ID:HIT214321797
Cas No:863202-33-9
常用名:CAY10498
IUPAC:N6-[(1S,2R,4R)-bicyclo[2.2.1]heptan-2-yl]-N2-phenyl-7H-purine-2,6-diamine
IUPAC:N6-[(1S,2R,4R)-bicyclo[2.2.1]heptan-2-yl]-N2-phenyl-7H-purine-2,6-diamine
InChI key:SLLSODGWHDUMRG-MBNYWOFBSA-N

分子式:C18H20N6
分子量:320.4
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC[C@@]([H])(C1)[C@@H](C2)Nc1nc(Nc2ccccc2)nc2nc[nH]c12 |TLB:9:7:6:2.3|
SMILES:[H][C@@]12CC[C@@]([H])(C1)[C@@H](C2)Nc1nc(Nc2ccccc2)nc2nc[nH]c12 |TLB:9:7:6:2.3|

The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation. A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective A3 AR antagonist exhibiting a Ki of 37 nM with 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively. CAY10498 is also a structural analog of reversine, a dedifferentiation agent of embryonic progenitor cells. However, no dedifferentiation effects or any connection between A3 AR antagonism and dedifferentiation have been demonstrated.

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