Name: Piericidin B
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321805
Cas No:16891-54-6
常用名:Piericidin B
IUPAC:2,3-dimethoxy-6-[(2E,5E,7E,9R,10R,11E)-10-methoxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl]-5-methylpyridin-4-ol
IUPAC:2,3-dimethoxy-6-[(2E,5E,7E,9R,10R,11E)-10-methoxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl]-5-methylpyridin-4-ol
InChI key:PTKGTYKMTXCJOK-DDSKRPRESA-N

分子式:C26H39NO4
分子量:429.601
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CO[C@H]([C@H](C)\C=C(/C)\C=C\C\C(C)=C\Cc1nc(OC)c(OC)c(O)c1C)C(\C)=C\C
SMILES:CO[C@H]([C@H](C)\C=C(/C)\C=C\C\C(C)=C\Cc1nc(OC)c(OC)c(O)c1C)C(\C)=C\C

Piericidin B is a bacterial metabolite that has been found inS. mobaraensisand has insecticidal and antimicrobial activities.1,2,3It inhibits NADH oxidase activity in isolated bovine heart mitochondria and inhibits respiration in isolated rat liver mitochondria and isolated cockroach (P. americana) muscle mitochondria.2,3Topical application of piericidin B (4 μg/insect) induces mortality in 87.5% of houseflies (M. domestica).1It induces 93.3, 100, and 100% mortality in rice stem borer (C. simples), silkworm (B. mori), and green caterpillar (P. rapae) larvae, respectively, when applied at respective concentrations of 60, 4.8, and 96 μg/larva. Piericidin B is active against the fungiT. asteroides,T. rubrum,M. gypseum, andC. neoforms(MICs = 20, 10, 20, and 2 μg/ml, respectively), as well as the bacteriaM. luteusandP. vulgaris(MICs = 50 and 100 μg/ml, respectively).

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