Name: Funalenone
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321816
Cas No:259728-61-5
常用名:Funalenone
IUPAC:3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one
IUPAC:3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one
InChI key:QAPJKCNKHLDDAK-UHFFFAOYSA-N

分子式:C15H12O6
分子量:288.255
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC1=C(O)c2c(O)cc(C)c3c(O)cc(O)c(C1=O)c23 |c:2|
SMILES:COC1=C(O)c2c(O)cc(C)c3c(O)cc(O)c(C1=O)c23 |c:2|

Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM). Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM. It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.

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