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  3. HIT214321817
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HIT214321817
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HIT214321817
  • HIT ID:HIT214321817
  • Cas No:83-85-2
  • 常用名:Fuscin
  • IUPAC:5-hydroxy-4,8,8-trimethyl-2H,4H,6H,8H,9H,10H-pyrano[3,2-f]isochromene-2,6-dione
    IUPAC:5-hydroxy-4,8,8-trimethyl-2H,4H,6H,8H,9H,10H-pyrano[3,2-f]isochromene-2,6-dione
  • InChI key:OSJKAGRXDVEZQO-UHFFFAOYSA-N
  • 分子式:C15H16O5
  • 分子量:276.288
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12 |t:5,7,19|
    SMILES:CC1OC(=O)C=C2C3=C(OC(C)(C)CC3)C(=O)C(O)=C12 |t:5,7,19|
  • Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner. It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 15,800.00
    1

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