Name: MMP-9 Inhibitor I
Rating: 5 (10 reviews)

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HIT ID:HIT214321821
Cas No:206549-55-5
常用名:MMP-9 Inhibitor I
IUPAC:2-(N-benzyl4-methoxybenzenesulfonamido)-5-[(diethylamino)methyl]-N-hydroxy-3-methylbenzamide
IUPAC:2-(N-benzyl4-methoxybenzenesulfonamido)-5-[(diethylamino)methyl]-N-hydroxy-3-methylbenzamide
InChI key:WRNMBFWQBKEBIX-UHFFFAOYSA-N

分子式:C27H33N3O5S
分子量:511.64
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCN(CC)Cc1cc(C)c(N(Cc2ccccc2)S(=O)(=O)c2ccc(OC)cc2)c(c1)C(=O)NO
SMILES:CCN(CC)Cc1cc(C)c(N(Cc2ccccc2)S(=O)(=O)c2ccc(OC)cc2)c(c1)C(=O)NO

MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.

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