Name: 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
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HIT ID:HIT214321847
Cas No:1621369-73-0
常用名:17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
常用名:17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
别名:17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
别名:17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide
InChI key:QLKKMIWGFNMQJQ-JZFYYOKZSA-N

分子式:C26H36F3NO4
分子量:483.572
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc1cccc(c1)C(F)(F)F
SMILES:CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc1cccc(c1)C(F)(F)F

Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2α) is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α ethyl amide is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α. Ethyl amides of PGs can serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

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