Name: JKE-1716
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321860
Cas No:2421118-05-8
常用名:JKE-1716
IUPAC:3-{4-[bis(4-chlorophenyl)methyl]piperazin-1-yl}-N'-hydroxy-N,N,3-trioxopropanimidamide
IUPAC:3-{4-[bis(4-chlorophenyl)methyl]piperazin-1-yl}-N'-hydroxy-N,N,3-trioxopropanimidamide
InChI key:HZFRTZXJNACSIE-UHFFFAOYSA-N

分子式:C20H20Cl2N4O4
分子量:451.3
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:ON=C(CC(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)N(=O)=O |w:1.0|
SMILES:ON=C(CC(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)N(=O)=O |w:1.0|

JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~