Name: PM226
Rating: 5 (10 reviews)

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HIT ID:HIT214321867
Cas No:1949726-13-9
常用名:PM226
别名:PM 226
IUPAC:9-methoxy-4,4-dimethyl-7-(2-methyloctan-2-yl)-4H-chromeno[3,4-d][1,2]oxazole
IUPAC:9-methoxy-4,4-dimethyl-7-(2-methyloctan-2-yl)-4H-chromeno[3,4-d][1,2]oxazole
InChI key:VFWIRWAAMNBBFG-UHFFFAOYSA-N

分子式:C22H31NO3
分子量:357.494
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCC(C)(C)c1cc(OC)c2-c3oncc3C(C)(C)Oc2c1
SMILES:CCCCCCC(C)(C)c1cc(OC)c2-c3oncc3C(C)(C)Oc2c1

Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microglial activation in a multiple sclerosis mouse model. BBB permeable; anti-inflammatory and neuroprotective.

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