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  3. HIT214321875
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HIT214321875
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HIT214321875
  • HIT ID:HIT214321875
  • Cas No:1233706-89-2
  • 常用名:CAY10641
  • IUPAC:1-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]-3-(2-methylpropanoyl)-1H-indole-5-carboxylic acid
    IUPAC:1-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]-3-(2-methylpropanoyl)-1H-indole-5-carboxylic acid
  • InChI key:BOEJDYFVYZETDG-UHFFFAOYSA-N
  • 分子式:C28H27NO6
  • 分子量:473.525
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(C)C(=O)c1cn(CC(O)COc2ccc(Oc3ccccc3)cc2)c2ccc(cc12)C(O)=O
    SMILES:CC(C)C(=O)c1cn(CC(O)COc2ccc(Oc3ccccc3)cc2)c2ccc(cc12)C(O)=O
  • Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.2CAY10641 is rapidly cleared from the blood stream (only 0.5 μg/ml remains 30 minutes after 10 mg/kg intravenous administration to mice).2However, no other biological effects have been reported.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,230.00
    1

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