Name: Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
Rating: 5 (10 reviews)

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HIT ID:HIT214321887
Cas No:39916-28-4
常用名:Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
常用名:Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
IUPAC:
IUPAC:
InChI key:GMBSBJACMGJDJH-UHFFFAOYSA-L

分子式:C20H14ClFeN2O2
分子量:405.64
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Cl-][Fe+3]123[O-]c4ccccc4C=[N]1c1ccccc1[N]2=Cc1ccccc1[O-]3 |c:10,21,^1:0,10,17|
SMILES:[Cl-][Fe+3]123[O-]c4ccccc4C=[N]1c1ccccc1[N]2=Cc1ccccc1[O-]3 |c:10,21,^1:0,10,17|

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging from 0.04 to 0.125 μM.2

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