Name: GLP-1(28-36)amide
Rating: 5 (10 reviews)

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HIT ID:HIT214321910
Cas No:1225021-13-5
常用名:GLP-1(28-36)amide
IUPAC:(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-amino-3-phenylpropanamido]-3-methylpentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-methylbutanamido]-N-({[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}methyl)hexanamide
IUPAC:(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-amino-3-phenylpropanamido]-3-methylpentanamido]propanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-methylbutanamido]-N-({[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}methyl)hexanamide
InChI key:AYAZRBWYYBZITR-MJCVNZGZSA-N

分子式:C54H85N15O9
分子量:1088.37
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
SMILES:CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O

GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it effectively inhibits mitochondrial permeability transition (MPT). This compound exhibits anti-diabetic properties and demonstrates cardioprotection effects[1].

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