Name: 17-phenyl trinor Prostaglandin F2α methyl amide
Rating: 5 (10 reviews)

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HIT ID:HIT214321935
Cas No:155206-01-2
常用名:17-phenyl trinor Prostaglandin F2α methyl amide
常用名:17-phenyl trinor Prostaglandin F2α methyl amide
别名:17-phenyl trinor Prostaglandin F2α methyl amide
别名:17-phenyl trinor Prostaglandin F2α methyl amide
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-methylhept-5-enamide
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-methylhept-5-enamide
InChI key:UWIWNJFBNIMMGY-FDBOBMRISA-N

分子式:C24H35NO4
分子量:401.547
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc1ccccc1
SMILES:CNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc1ccccc1

17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The ethyl amide of 17-phenyl trinor PGF2α bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF2α methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated.

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