Name: 17-trifluoromethylphenyl trinor Prostaglandin F2α
Rating: 5 (10 reviews)

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HIT ID:HIT214321936
Cas No:221246-34-0
常用名:17-trifluoromethylphenyl trinor Prostaglandin F2α
常用名:17-trifluoromethylphenyl trinor Prostaglandin F2α
别名:17-trifluoromethylphenyl trinor Prostaglandin F2α
别名:17-trifluoromethylphenyl trinor Prostaglandin F2α
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pent-1-en-1-yl]cyclopentyl]hept-5-enoic acid
IUPAC:(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pent-1-en-1-yl]cyclopentyl]hept-5-enoic acid
InChI key:CMLNDCUXASGBMQ-NQUQXYBYSA-N

分子式:C24H31F3O5
分子量:456.502
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:O[C@@H](CCc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
SMILES:O[C@@H](CCc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.

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