Name: N-methyl Leukotriene C4
Rating: 5 (10 reviews)

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HIT ID:HIT214321962
Cas No:131391-65-6
常用名:N-methyl Leukotriene C4
别名:N-methyl Leukotriene C4
IUPAC:(5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-carboxy-4-(methylamino)butanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
IUPAC:(5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-[(4S)-4-carboxy-4-(methylamino)butanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
InChI key:FPLBRCJNODNRQZ-UYCXAPQFSA-N

分子式:C31H49N3O9S
分子量:639.81
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](NC)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
SMILES:CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](NC)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

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