Name: GM 1489
Rating: 5 (10 reviews)

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HIT ID:HIT214321963
Cas No:171347-75-4
常用名:GM 1489
IUPAC:(3R)-3-{[(1S)-2-(1H-indol-3-yl)-1-{[(1S)-1-phenylethyl]carbamoyl}ethyl]carbamoyl}-5-methylhexanoic acid
IUPAC:(3R)-3-{[(1S)-2-(1H-indol-3-yl)-1-{[(1S)-1-phenylethyl]carbamoyl}ethyl]carbamoyl}-5-methylhexanoic acid
InChI key:BLPWNGOQQLJQOL-NRYAXDJKSA-N

分子式:C27H33N3O4
分子量:463.578
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)C[C@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)c1ccccc1
SMILES:CC(C)C[C@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)c1ccccc1

GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate and phorbol dibutyrate (PdiBu) in mice.

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