Name: LEO 39652
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214321972
Cas No:1445656-91-6
常用名:LEO 39652
IUPAC:2-methylpropyl 1-[8-methoxy-5-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate
IUPAC:2-methylpropyl 1-[8-methoxy-5-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate
InChI key:LUUUHUYQTLUIDG-UHFFFAOYSA-N

分子式:C23H23N3O5
分子量:421.453
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C
SMILES:COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C

LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1].

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