Name: Herquline A
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214321980
Cas No:71812-08-3
常用名:Herquline A
IUPAC:(2S,3R,7R,8R,14S,17S)-15-methyl-1,15-diazapentacyclo[12.3.1.1^{3,17}.1^{8,12}.0^{2,7}]icos-12(20)-ene-6,9-dione
IUPAC:(2S,3R,7R,8R,14S,17S)-15-methyl-1,15-diazapentacyclo[12.3.1.1^{3,17}.1^{8,12}.0^{2,7}]icos-12(20)-ene-6,9-dione
InChI key:UFKNDVKQCSBIQE-OCANJJRCSA-N

分子式:C19H26N2O2
分子量:314.429
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12C[C@@]3([H])CCC(=O)[C@@]4([H])[C@@]3([H])N1C[C@]([H])(CC1=C[C@@]4([H])C(=O)CC1)N(C)C2 |t:20|
SMILES:[H][C@@]12C[C@@]3([H])CCC(=O)[C@@]4([H])[C@@]3([H])N1C[C@]([H])(CC1=C[C@@]4([H])C(=O)CC1)N(C)C2 |t:20|

Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively).

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