Name: Glycerophospho-N-Palmitoyl Ethanolamine
Rating: 5 (10 reviews)

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HIT ID:HIT214321997
Cas No:100575-09-5
常用名:Glycerophospho-N-Palmitoyl Ethanolamine
常用名:Glycerophospho-N-Palmitoyl Ethanolamine
IUPAC:(2,3-dihydroxypropoxy)(2-hexadecanamidoethoxy)phosphinic acid
IUPAC:(2,3-dihydroxypropoxy)(2-hexadecanamidoethoxy)phosphinic acid
InChI key:FIXMIXZULLAMCB-UHFFFAOYSA-N

分子式:C21H44NO7P
分子量:453.557
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCCCCCCCCCC(=O)NCCOP(O)(=O)OCC(O)CO
SMILES:CCCCCCCCCCCCCCCC(=O)NCCOP(O)(=O)OCC(O)CO

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is the metabolic precursor of palmitoyl ethanolamide (PEA). PEA is an endogenous cannabinoid found in brain, liver, and other mammalian tissues, that has potent anti-inflammatory activity in vivo. PEA has low affinity for peripheral cannabinoid (CB2) and no appreciable affinity for central cannabinoid (CB1), suggesting that its efficacy is through a different receptor.

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