Name: Salvinorin A Propionate
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214322001
Cas No:689295-71-4
常用名:Salvinorin A Propionate
IUPAC:methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-9-(propanoyloxy)-dodecahydro-1H-naphtho[2,1-c]pyran-7-carboxylate
IUPAC:methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-9-(propanoyloxy)-dodecahydro-1H-naphtho[2,1-c]pyran-7-carboxylate
InChI key:UPFVFWZGNRKYFG-ZWLNRFIDSA-N

分子式:C24H30O8
分子量:446.496
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(=O)CC)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c1ccoc1)C(=O)OC
SMILES:[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(=O)CC)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c1ccoc1)C(=O)OC

Salvinorin A propionate is a selective partial agonist at κ1-opioid receptors (KOR) with a Ki value of 32.6 nM. It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR. It is selective for KORs over μ, δ, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 μg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A .

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