Name: 20-hydroxy Leukotriene B4
Rating: 5 (10 reviews)

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HIT ID:HIT214322018
Cas No:79516-82-8
常用名:20-hydroxy Leukotriene B4
别名:20-hydroxy Leukotriene B4
IUPAC:(5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
IUPAC:(5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
InChI key:PTJFJXLGRSTECQ-PSPARDEHSA-N

分子式:C20H32O5
分子量:352.471
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
SMILES:OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.

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