Name: Antibiotic PF 1052
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214322022
Cas No:147317-15-5
常用名:Antibiotic PF 1052
IUPAC:5-(butan-2-yl)-3-{[2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-1-methylpyrrolidine-2,4-dione
IUPAC:5-(butan-2-yl)-3-{[2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-1-methylpyrrolidine-2,4-dione
InChI key:NPWKEUKXVOMELT-UHFFFAOYSA-N

分子式:C26H39NO4
分子量:429.601
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCC(C)C1N(C)C(=O)C(=C(O)C2C(C=CC3CC(C)CC(C)C23)C2(C)OC2C)C1=O |w:10.10,c:14|
SMILES:CCC(C)C1N(C)C(=O)C(=C(O)C2C(C=CC3CC(C)CC(C)C23)C2(C)OC2C)C1=O |w:10.10,c:14|

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 μM.

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