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  3. HIT214322026
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HIT214322026
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HIT214322026
  • HIT ID:HIT214322026
  • Cas No:1831135-30-8
  • 常用名:JJH260
  • 别名:JJH260
  • IUPAC:7-[4-(dimethylamino)benzoyl]-1,3-dioxo-octahydroimidazo[1,5-a]pyrazin-2-yl 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate
    IUPAC:7-[4-(dimethylamino)benzoyl]-1,3-dioxo-octahydroimidazo[1,5-a]pyrazin-2-yl 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate
  • InChI key:RISSJZZMOJQTIN-UHFFFAOYSA-N
  • 分子式:C29H34ClN5O5
  • 分子量:568.07
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CN(C)c1ccc(cc1)C(=O)N1CCN2C(C1)C(=O)N(OC(=O)N1CCC(CCc3ccc(Cl)cc3)CC1)C2=O
    SMILES:CN(C)c1ccc(cc1)C(=O)N1CCN2C(C1)C(=O)N(OC(=O)N1CCC(CCc3ccc(Cl)cc3)CC1)C2=O
  • JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 5,680.00
    1

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