Name: Platencin
Rating: 5 (10 reviews)

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HIT ID:HIT214322032
Cas No:869898-86-2
常用名:Platencin
IUPAC:2,4-dihydroxy-3-{3-[(1S,5S,6R,8S)-5-methyl-9-methylidene-4-oxotricyclo[6.2.2.0^{1,6}]dodec-2-en-5-yl]propanamido}benzoic acid
IUPAC:2,4-dihydroxy-3-{3-[(1S,5S,6R,8S)-5-methyl-9-methylidene-4-oxotricyclo[6.2.2.0^{1,6}]dodec-2-en-5-yl]propanamido}benzoic acid
InChI key:DWUHGPPFFABTIY-RLWZQHMASA-N

分子式:C24H27NO6
分子量:425.481
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC[C@]3(CC1=C)C=CC(=O)[C@@](C)(CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)[C@]3([H])C2 |c:9,TLB:12:30:5.6:2.3|
SMILES:[H][C@@]12CC[C@]3(CC1=C)C=CC(=O)[C@@](C)(CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)[C@]3([H])C2 |c:9,TLB:12:30:5.6:2.3|

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.

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