ACEA | Arachidonoyl 2'-Chloroethylamide | 2'-chloro-AEA | CAS 220556-69-4 | AnyMole

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HIT214322041

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HIT214322041

HIT ID:HIT214322041
Cas No:220556-69-4
常用名:ACEA
别名:Arachidonoyl 2'-Chloroethylamide, 2'-chloro-AEA
别名:Arachidonoyl 2'-Chloroethylamide, 2'-chloro-AEA
IUPAC:(5Z,8Z,11Z,14Z)-N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide
IUPAC:(5Z,8Z,11Z,14Z)-N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide
InChI key:SCJNCDSAIRBRIA-DOFZRALJSA-N

分子式:C22H36ClNO
分子量:365.99
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl
SMILES:CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl

Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

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