Name: Gilvocarcin M
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322044
Cas No:77879-89-1
常用名:Gilvocarcin M
IUPAC:12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-15-hydroxy-3,17-dimethoxy-5-methyl-9-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2(7),3,5,11(16),12,14,17-octaen-8-one
IUPAC:12-[(2R,3R,4R,5S)-3,4-dihydroxy-5-[(1R)-1-hydroxyethyl]oxolan-2-yl]-15-hydroxy-3,17-dimethoxy-5-methyl-9-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2(7),3,5,11(16),12,14,17-octaen-8-one
InChI key:BYFOTBZTKXSZHH-FUCVEXJHSA-N

分子式:C26H26O9
分子量:482.485
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]1(O[C@@H]([C@H](O)[C@H]1O)c1ccc(O)c2c(OC)cc3c(oc(=O)c4cc(C)cc(OC)c34)c12)[C@@H](C)O
SMILES:[H][C@]1(O[C@@H]([C@H](O)[C@H]1O)c1ccc(O)c2c(OC)cc3c(oc(=O)c4cc(C)cc(OC)c34)c12)[C@@H](C)O

Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus. It is active against S. aureus when used at a concentration of 32 μg/ml. Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 μg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg. Gilvocarcin M intercalates into bacteriophage PM2 DNA. It is toxic to rats with an intravenous LD50 value of 450 mg/kg.

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