Name: STING Agonist 12b
Rating: 5 (10 reviews)

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HIT ID:HIT214322047
Cas No:2411100-70-2
常用名:STING Agonist 12b
IUPAC:2-methoxy-5,6-dimethyl-9,10-dihydroacridin-9-one
IUPAC:2-methoxy-5,6-dimethyl-9,10-dihydroacridin-9-one
InChI key:SEVGTQHWWAYAQR-UHFFFAOYSA-N

分子式:C16H15NO2
分子量:253.301
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc2[nH]c3c(C)c(C)ccc3c(=O)c2c1
SMILES:COc1ccc2[nH]c3c(C)c(C)ccc3c(=O)c2c1

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells.

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