Name: N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
Rating: 5 (10 reviews)

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HIT ID:HIT214322077
Cas No:1258011-97-0
常用名:N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
常用名:N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
IUPAC:(9Z)-N-[1-(3,4-dihydroxyphenyl)propan-2-yl]octadec-9-enamide
IUPAC:(9Z)-N-[1-(3,4-dihydroxyphenyl)propan-2-yl]octadec-9-enamide
InChI key:XIPFMGYXSZQUGV-KHPPLWFESA-N

分子式:C27H45NO3
分子量:431.661
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCC\C=C/CCCCCCCC(=O)NC(C)Cc1ccc(O)c(O)c1
SMILES:CCCCCCCC\C=C/CCCCCCCC(=O)NC(C)Cc1ccc(O)c(O)c1

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).

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