Name: CU-76
Rating: 5 (10 reviews)

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HIT ID:HIT214322134
Cas No:2400954-58-5
常用名:CU-76
IUPAC:methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate
IUPAC:methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate
InChI key:DATILFYUDSRBBK-UHFFFAOYSA-N

分子式:C11H8F2IN5O2
分子量:407.119
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)c1nc(N)nc(Nc2cc(F)c(I)c(F)c2)n1
SMILES:COC(=O)c1nc(N)nc(Nc2cc(F)c(I)c(F)c2)n1

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

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