Name: CAY10597
Rating: 5 (10 reviews)

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HIT ID:HIT214322149
Cas No:916046-55-4
常用名:CAY10597
IUPAC:2-{5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-1-yl}acetic acid
IUPAC:2-{5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-1-yl}acetic acid
InChI key:SKLDVYDFQCXARY-UHFFFAOYSA-N

分子式:C20H14ClFN2O5
分子量:416.79
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12
SMILES:OC(=O)CN1C(=O)C2(CC(=O)N(Cc3ccccc3F)C2=O)c2cc(Cl)ccc12

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D2 with an IC50 value of 40 nM.

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