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  3. HIT214322157
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HIT214322157
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HIT214322157
  • HIT ID:HIT214322157
  • Cas No:2414916-45-1
  • 常用名:ADTL-EI1712
  • 别名:ADTL-EI1712
  • IUPAC:2-(2-chlorobenzamido)-6-[(2-chlorophenyl)carbamothioyl]-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxamide
    IUPAC:2-(2-chlorobenzamido)-6-[(2-chlorophenyl)carbamothioyl]-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxamide
  • InChI key:LVSFMPVPLIMFMY-UHFFFAOYSA-N
  • 分子式:C22H18Cl2N4O2S2
  • 分子量:505.43
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:NC(=O)c1c(NC(=O)c2ccccc2Cl)sc2CN(CCc12)C(=S)Nc1ccccc1Cl
    SMILES:NC(=O)c1c(NC(=O)c2ccccc2Cl)sc2CN(CCc12)C(=S)Nc1ccccc1Cl
  • ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a dose of 50 mg/kg per day.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
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    ¥ 1,560.00
    1

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