Name: Conantokin-R
Rating: 5 (10 reviews)

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HIT ID:HIT214322163
Cas No:202925-60-8
常用名:Conantokin-R
IUPAC:2-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-5-amino-1-[({[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(carbamoylmethyl)-4-{[(2S)-1-[(2S)-2-carboxypyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl}-6,9,12,15-tetraoxo-10-(propan-2-yl)-1,2-dithia-5,8,11,14-tetraazacycloheptadecan-16-yl]carbamoyl}methyl)carbamoyl]pentyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-3,3-dicarboxypropyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-(2-aminoacetamido)-4-carboxybutanamido]-4,4-dicarboxybutanamido]-4,4-dicarboxybutanamido]-3-methylbutanamido]propanamido]hexanamido]-4-(methylsulfanyl)butanamido]propanamido]propanamido]ethyl]propanedioic acid
IUPAC:2-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(1S)-1-{[(1S)-5-amino-1-[({[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(carbamoylmethyl)-4-{[(2S)-1-[(2S)-2-carboxypyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl}-6,9,12,15-tetraoxo-10-(propan-2-yl)-1,2-dithia-5,8,11,14-tetraazacycloheptadecan-16-yl]carbamoyl}methyl)carbamoyl]pentyl]carbamoyl}ethyl]carbamoyl}-2-methylbutyl]carbamoyl}-2-carbamoylethyl]carbamoyl}-3,3-dicarboxypropyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}ethyl]carbamoyl}-3-methylbutyl]carbamoyl}-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-(2-aminoacetamido)-4-carboxybutanamido]-4,4-dicarboxybutanamido]-4,4-dicarboxybutanamido]-3-methylbutanamido]propanamido]hexanamido]-4-(methylsulfanyl)butanamido]propanamido]propanamido]ethyl]propanedioic acid
InChI key:MJQQZSPLVNQFRB-HHXUSTKESA-N

分子式:C127H201N35O49S3
分子量:3098.38
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC1=O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(O)=O |@@:135|
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC1=O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(O)=O |@@:135|

Conantokin-R 是一种 NMDA 受体肽拮抗剂（IC50=93 nM）；Conantokin-R 显示出抗惊厥活性；Conantokin-R 可以与 Zn2+ 和 Mg2+ 结合（Kds 分别为 0.15 μM 和 6.5 μM）。

市场产品/服务共显示1个结果

供应商
TargetMolSC
规格
货期
纯度
-
¥ 8,749.00
1

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