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  3. HIT214322207
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HIT214322207
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HIT214322207
  • HIT ID:HIT214322207
  • Cas No:1048660-43-0
  • 常用名:ROC-0929
  • IUPAC:N-(benzenesulfonyl)-2-{[1-benzyl-3-(carbamoylcarbonyl)-2-(2-methylpropyl)-1H-indol-4-yl]oxy}propanamide
    IUPAC:N-(benzenesulfonyl)-2-{[1-benzyl-3-(carbamoylcarbonyl)-2-(2-methylpropyl)-1H-indol-4-yl]oxy}propanamide
  • InChI key:REUKAAAAEHWGGM-UHFFFAOYSA-N
  • 分子式:C30H31N3O6S
  • 分子量:561.65
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(C)Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
    SMILES:CC(C)Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
  • ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), effectively targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, belonging to the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, resulting in the release of a fatty acid and a lysophospholipid. ROC-0929 holds promise in researching inflammation-related diseases.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,400.00
    1

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