Name: Ac-hMCH(6-16)-NH2
Rating: 5 (10 reviews)

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HIT ID:HIT214322211
Cas No:1053601-50-5
常用名:Ac-hMCH(6-16)-NH2
别名:Ac-hMCH(6-16)-NH2
IUPAC:(2S)-N-({[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1R)-1-carbamoyl-2-sulfanylethyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butyl]carbamoyl}methyl)-2-[(2S)-2-[(2R)-2-[(2S)-5-carbamimidamido-2-acetamidopentanamido]-3-sulfanylpropanamido]-4-(methylsulfanyl)butanamido]-4-methylpentanamide
IUPAC:(2S)-N-({[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1R)-1-carbamoyl-2-sulfanylethyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butyl]carbamoyl}methyl)-2-[(2S)-2-[(2R)-2-[(2S)-5-carbamimidamido-2-acetamidopentanamido]-3-sulfanylpropanamido]-4-(methylsulfanyl)butanamido]-4-methylpentanamide
InChI key:GCUCBSVZUDAARP-IHLBVCFISA-N

分子式:C58H99N21O13S3
分子量:1394.74
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(N)=O |@:53|
SMILES:CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(N)=O |@:53|

Ac-hMCH(6-16)-NH2 shows non-selective agonist activity towards both MCH-1R and MCH-2R, which are human MCH receptors in the brain. The compound effectively binds to and activates these receptors, with IC 50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R, respectively.

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