Name: PF-03622905
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322219
Cas No:1072100-15-2
常用名:PF-03622905
IUPAC:N-{5-[(2S,5R)-5-(2-hydroxyethyl)-2-methyl-4-propylpiperazine-1-carbonyl]-6,6-dimethyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}pyridine-2-carboxamide
IUPAC:N-{5-[(2S,5R)-5-(2-hydroxyethyl)-2-methyl-4-propylpiperazine-1-carbonyl]-6,6-dimethyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}pyridine-2-carboxamide
InChI key:SYMKCZOALSNIBQ-DLBZAZTESA-N

分子式:C24H35N7O3
分子量:469.59
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCN1C[C@H](C)N(C[C@H]1CCO)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
SMILES:CCCN1C[C@H](C)N(C[C@H]1CCO)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C

PF-03622905, a potent and ATP-competitive PKC inhibitor, exhibits IC50 values of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. Notably, PF-03622905 demonstrates high specificity for PKC in comparison to other protein kinases.

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