Name: PF-04577806
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322220
Cas No:1072100-81-2
常用名:PF-04577806
IUPAC:N-{5-[(2S,5R)-2,5-dimethyl-4-[(oxan-4-yl)methyl]piperazine-1-carbonyl]-6,6-dimethyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}pyridine-2-carboxamide
IUPAC:N-{5-[(2S,5R)-2,5-dimethyl-4-[(oxan-4-yl)methyl]piperazine-1-carbonyl]-6,6-dimethyl-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}pyridine-2-carboxamide
InChI key:WIUOWTNXQICTJG-MSOLQXFVSA-N

分子式:C26H37N7O3
分子量:495.628
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
SMILES:C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C

PF-04577806 is a potent, selective, and ATP competitive inhibitor of the protein kinase C (PKC). It exhibits significant inhibitory activity against various isoforms of PKC, including PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, with IC50 values of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. Furthermore, PF-04577806 has the ability to reverse retinal vascular leakage in diabetic rats.

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