ALK-IN-12 | CAS 1197958-53-4 | AnyMole

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HIT214322297

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HIT214322297

HIT ID:HIT214322297
Cas No:1197958-53-4
常用名:ALK-IN-12
IUPAC:5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidine-2,4-diamine
IUPAC:5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidine-2,4-diamine
InChI key:YHWJHUBPWLCING-UHFFFAOYSA-N

分子式:C24H30ClN6O2P
分子量:500.97
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCN(C)CC1
SMILES:COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCN(C)CC1

ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like growth factor 1 receptor (IGF1R) and insulin receptor (InsR), with IC50 values of 20.3 nM and 90.6 nM, respectively. Notably, its antitumor effects have been observed, making it a promising compound for targeted cancer therapy.

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TargetMolSC
规格
货期
6-8周
纯度
-
¥ 10,600.00
1

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