Name: Prexasertib dimesylate
Rating: 5 (10 reviews)

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HIT ID:HIT214322321
Cas No:1234015-58-7
常用名:Prexasertib dimesylate
别名:LY2606368 dimesylate
IUPAC:5-({5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile; bis(methanesulfonic acid)
IUPAC:5-({5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile; bis(methanesulfonic acid)
InChI key:HXYBEKZGRNUTBN-UHFFFAOYSA-N

分子式:C20H27N7O8S2
分子量:557.6
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CS(O)(=O)=O.CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
SMILES:CS(O)(=O)=O.CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectively inhibits CHK2 (IC 50 = 8 nM) and RSK1 (IC 50 = 9 nM). Its mechanism of action involves inducing double-stranded DNA breakage and replication catastrophe, ultimately leading to apoptosis. Moreover, Prexasertib dimesylate demonstrates potent anti-tumor activity.

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