Name: AP 811
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214322340
Cas No:124833-45-0
常用名:AP 811
IUPAC:3-({4-carbamimidamido-1-[(2-methylbutyl)carbamoyl]butyl}carbamoyl)-3-[2-(5-carbamimidamido-2-{2-[4-(naphthalene-2-amido)phenyl]acetamido}pentanamido)-3-methylpentanamido]propanoic acid
IUPAC:3-({4-carbamimidamido-1-[(2-methylbutyl)carbamoyl]butyl}carbamoyl)-3-[2-(5-carbamimidamido-2-{2-[4-(naphthalene-2-amido)phenyl]acetamido}pentanamido)-3-methylpentanamido]propanoic acid
InChI key:UNMJSSQZDQBGDS-UHFFFAOYSA-N

分子式:C46H66N12O8
分子量:915.11
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCC(C)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(C)CC
SMILES:CCC(C)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(C)CC

AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.

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