Name: Fabesetron
Rating: 5 (10 reviews)

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HIT ID:HIT214322383
Cas No:129300-27-2
常用名:Fabesetron
别名:法贝司琼, FK1052 free base
IUPAC:(7R)-10-methyl-7-[(4-methyl-1H-imidazol-5-yl)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-6-one
IUPAC:(7R)-10-methyl-7-[(4-methyl-1H-imidazol-5-yl)methyl]-6H,7H,8H,9H-pyrido[1,2-a]indol-6-one
InChI key:AEKQMJRJRAHOAP-CYBMUJFWSA-N

分子式:C18H19N3O
分子量:293.37
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1nc[nH]c1C[C@H]1CCc2c(C)c3ccccc3n2C1=O
SMILES:Cc1nc[nH]c1C[C@H]1CCc2c(C)c3ccccc3n2C1=O

Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for managing both acute and delayed symptoms.

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