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  3. HIT214322390
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HIT214322390
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HIT214322390
  • HIT ID:HIT214322390
  • Cas No:1311143-71-1
  • 常用名:JH295
  • IUPAC:N-[(3Z)-3-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl]prop-2-ynamide
    IUPAC:N-[(3Z)-3-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl]prop-2-ynamide
  • InChI key:ORKOHXAJFGRZCL-LCYFTJDESA-N
  • 分子式:C18H16N4O2
  • 分子量:320.352
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCc1nc(C)c(\C=C2/C(=O)Nc3ccc(NC(=O)C#C)cc23)[nH]1
    SMILES:CCc1nc(C)c(\C=C2/C(=O)Nc3ccc(NC(=O)C#C)cc23)[nH]1
  • JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 4,380.00
    1

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