Name: E67-2
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT214322441
Cas No:1364914-62-4
常用名:E67-2
别名:E67-2
IUPAC:7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine
IUPAC:7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine
InChI key:WLFIYSGBVULZIU-UHFFFAOYSA-N

分子式:C21H36N6O2
分子量:404.559
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2c(nc(NCCCN(C)C)nc2cc1OCCCCCN)N(C)C
SMILES:COc1cc2c(nc(NCCCN(C)C)nc2cc1OCCCCCN)N(C)C

E67-2, a derivative of E67, is a low-toxicity, selective inhibitor of the KIAA1718 Jumonji domain. It has an IC 50 value of 3.4 μM. E67-2 specifically inhibits the Jumonji demethylase for histone H3 lysine 9 (H3K9) and histone H3 lysine 4 (H3K4) demethylase.

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