Name: MMPI-1154
Rating: 5 (10 reviews)

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HIT ID:HIT214322460
Cas No:1382722-47-5
常用名:MMPI-1154
IUPAC:2-[({[4-(benzyloxy)phenyl]methyl}[(4-fluorophenyl)methyl]amino)methyl]-1H-imidazole-5-carboxylic acid
IUPAC:2-[({[4-(benzyloxy)phenyl]methyl}[(4-fluorophenyl)methyl]amino)methyl]-1H-imidazole-5-carboxylic acid
InChI key:QLTNFRCPUOPISS-UHFFFAOYSA-N

分子式:C26H24FN3O3
分子量:445.494
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)c1cnc(CN(Cc2ccc(F)cc2)Cc2ccc(OCc3ccccc3)cc2)[nH]1
SMILES:OC(=O)c1cnc(CN(Cc2ccc(F)cc2)Cc2ccc(OCc3ccccc3)cc2)[nH]1

MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively.

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